Fluticasone / Salmeterol
Also known as: Advair, Advair HFA, Airduo, Fluticasone-Salmeterol, Wixela.
Wholesale (NADAC) cost for every strength and dosage form — the price pharmacies pay, published weekly by CMS. Not your out-of-pocket price.
Wholesale (NADAC) prices — every strength & form
| Strength | Form | NADAC / unit | Package | Class |
|---|---|---|---|---|
| 45-21 MCG | Inhaler | $20.02 / gram | $240.28 / 12 GM box | Brand |
| 45-21 | (unspecified) | $16.79 / gram | — | Generic |
| 55-14 | (unspecified) | $111.44 / unit | — | Generic |
| 100-50 | Inhaler | $1.14 / unit | $68.23 / 60 EA box | Generic |
| 100-50 | (unspecified) | $1.14 / unit | — | Generic |
| 113-14 | (unspecified) | $113.81 / unit | — | Generic |
| 115-21 MCG | Inhaler | $22.07 / gram | $264.86 / 12 GM box | Brand |
| 115-21 | (unspecified) | $20.65 / gram | — | Generic |
| 230-21 MCG | Inhaler | $32.84 / gram | $394.04 / 12 GM box | Brand |
| 230-21 | (unspecified) | $27.44 / gram | — | Generic |
| 232-14 | (unspecified) | $103.38 / unit | — | Generic |
| 250-50 | Inhaler | $1.32 / unit | $78.93 / 60 EA box | Generic |
| 250-50 | (unspecified) | $1.32 / unit | — | Generic |
| 500-50 | Inhaler | $1.61 / unit | $96.72 / 60 EA box | Generic |
| 500-50 | (unspecified) | $1.61 / unit | — | Generic |
Wholesale (NADAC) — the price pharmacies pay, not your out-of-pocket price. Brand list prices fall after confidential rebates. Liquids, creams, and sprays are priced per mL or gram; a typical package may be a bottle or tube (size not set yet). Box prices are per full package where the size is known.
NADAC week of 2026-07-01 · updated weekly · source CMS
Medicaid & Medicare spending · 2024
In 2024, Medicaid paid $434,658,294 gross for Fluticasone / Salmeterol across 1,941,283 prescriptions (measured, national).
Medicare Part D EST spent an estimated ~$441,493,221 gross (retail pharmacy only; excludes Part B).
Gross program spending, before rebates — not what patients pay out of pocket. Brand net cost is materially lower after confidential rebates; generics are close to net.
Source: Medicaid SDUD 2024 · Medicare Part D 2024 · CMS