Estradiol
Also known as: Climara, Delestrogen, Depo-Estradiol, Divigel, Dotti, Elestrin, Estrace, Estring, Estrogel, Evamist, Femring, Imvexxy and 7 more.
Wholesale (NADAC) cost for every strength and dosage form — the price pharmacies pay, published weekly by CMS. Not your out-of-pocket price.
Wholesale (NADAC) prices — every strength & form
| Strength | Form | NADAC / unit | Package | Class |
|---|---|---|---|---|
| 0.01% | Cream | $0.389 / gram | — | Generic |
| 0.025 MG | Patch | $7.76 / unit | — | Generic |
| 0.0375 MG | Patch | $7.81 / unit | — | Generic |
| 0.05 MG | Patch | $7.77 / unit | — | Generic |
| 0.05 MG | Ring | $867.52 / unit† | — | Brand |
| 0.06 MG | Patch | $12.77 / unit | — | Generic |
| 0.06% | Gel | $3.61 / gram | — | Brand |
| 0.06% | (unspecified) | $3.50 / gram | — | Generic |
| 0.075 MG | Patch | $7.30 / unit | — | Generic |
| 0.1 MG | Patch | $7.33 / unit | — | Generic |
| 0.1% | (unspecified) | $1.36 / unit | — | Generic |
| 0.1% | Packet | $1.32 / unit | — | Generic |
| 0.10 MG | Ring | $928.58 / unit† | — | Brand |
| 0.25 MG | Packet | $5.39 / unit | — | Brand |
| 0.5 MG | Packet | $5.40 / unit | — | Brand |
| 0.5 MG | Tablet | $0.059 / unit | — | Generic |
| 0.75 MG | Packet | $5.37 / unit | — | Brand |
| 1 MG | Packet | $5.37 / gram | — | Brand |
| 1 MG | Tablet | $0.065 / unit | — | Generic |
| 1.25 MG | Packet | $4.29 / gram | — | Brand |
| 1.53 MG | (unspecified) | $18.22 / mL | — | Brand |
| 2 MG | Tablet | $0.081 / unit | — | Generic |
| 4 MCG | Packet | $27.10 / unit | — | Brand |
| 5 MG/ML | Vial | $51.91 / mL† | — | Brand |
| 7.5 MCG | Ring | $551.29 / unit† | — | Brand |
| 10 MCG | (unspecified) | $6.06 / unit | — | Generic |
| 10 MCG | Packet | $27.07 / unit | — | Brand |
| 10 MCG | Tablet | $20.33 / unit | — | Brand |
| 10 MCG | Insert | $6.06 / unit† | — | Generic |
| 14 MCG | Patch | $38.73 / unit | — | Brand |
| 50 MG/5 ML | Vial | $25.55 / mL† | — | Brand |
| 50 MG/5 ML | (unspecified) | $18.25 / mL | — | Generic |
| 100 MG/5 ML | Vial | $35.84 / mL† | — | Brand |
| 100 MG/5 ML | (unspecified) | $20.90 / mL | — | Generic |
| 200 MG/5 ML | (unspecified) | $34.18 / mL | — | Generic |
Wholesale (NADAC) — the price pharmacies pay, not your out-of-pocket price. Brand list prices fall after confidential rebates. † Package size not curated yet — priced per single unit/mL, not per full pen, inhaler, or vial. Liquids, creams, and sprays are priced per mL or gram; a typical package may be a bottle or tube (size not set yet).
NADAC week of 2026-07-01 · updated weekly · source CMS
Medicaid & Medicare spending · 2024
In 2024, Medicaid paid $72,598,550 gross for Estradiol across 1,446,608 prescriptions (measured, national).
Medicare Part D EST spent an estimated ~$220,012,858 gross (retail pharmacy only; excludes Part B).
Gross program spending, before rebates — not what patients pay out of pocket. Brand net cost is materially lower after confidential rebates; generics are close to net.
Source: Medicaid SDUD 2024 · Medicare Part D 2024 · CMSBuy it with a cash program — no insurance needed
0.5 MG · Tablet
TrumpRx discount card$6.85 · 30 tablets — $9.55 · 60 tablets — $12.71 · 90 tablets
Amazon Pharmacy (mail)$6.85 · 30 tablets — $12.71 · 90 tablets — $13.20 · 60 tablets
Cost Plus Drugs (mail)$11.29 · 30 tablets — $12.32 · 60 tablets — $13.36 · 90 tablets
1 MG · Tablet
TrumpRx discount card$6.82 · 30 tablets — $9.39 · 60 tablets — $11.96 · 90 tablets
Amazon Pharmacy (mail)$9.03 · 30 tablets — $13.56 · 90 tablets — $17.56 · 60 tablets
Cost Plus Drugs (mail)$12.02 · 30 tablets — $13.78 · 60 tablets — $15.55 · 90 tablets
2 MG · Tablet
TrumpRx discount card$7.53 · 30 tablets — $10.84 · 60 tablets — $13.75 · 90 tablets
Amazon Pharmacy (mail)$7.53 · 30 tablets — $13.75 · 90 tablets — $14.56 · 60 tablets
Cost Plus Drugs (mail)$12.09 · 30 tablets — $13.92 · 60 tablets — $15.76 · 90 tablets
Fixed program prices at participating pharmacies or by mail. Covered strengths & quantities only; program terms apply. TrumpRx card & mail-order prices as listed on trumprx.gov (updated weekly). Mail orders take days to arrive.